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Ophthalmology Xagena

Uveitis-related ocular hypertension: clinical profile


The clinical and demographic profile of uveitis-related ocular hypertension ( OHT ) was studied and risk factors predisposing to development of ocular hypertension in uveitis were evaluated.

Two hundred patients ( 200 eyes ) with uveitis were evaluated for type of uveitis and the presence of ocular hypertension [ intraocular pressure ( IOP ) more than 21 mmHg ].
All patients underwent a complete ophthalmic examination and appropriate systemic evaluation.

Patients with ocular hypertension were started on appropriate antiglaucoma medication and were followed up for minimum of 6 months.
Forty-two eyes ( 21% ) were found to have ocular hypertension. Anterior uveitis alone was seen in 22 ( 52.4 % ), granulomatous uveitis was seen in 8 ( 19.1% ) eyes, while 13 eyes ( 30.9% ) had active uveitis.

On multiple logistic regression, age greater than 60 years ( p=0.025 ), peripheral anterior synechiae ( PAS ) more than 180° ( p=0.029 ), and steroid use ( p less than 0.001 ) were found to have significant association with ocular hypertension.

Mean IOP at baseline was 24.6 ± 10.1 mmHg which decreased to 17.3 ± 4.5 mmHg at 6 months ( p less than 0.001 ).

At 6 months, 30 eyes were medically controlled ( 71.4% ), 5 eyes underwent trabeculectomy with MMC ( 11.9% ), and in 7 eyes, antiglaucoma medication could be discontinued.
One-fifth of eyes with uveitis had ocular hypertension. Risk factors for IOP elevation included increased age, PAS more than 180°, and corticosteroid use. ( Xagena )

Mahajan D et al, Int Ophthalmol 2014; Epub ahead of print

XagenaMedicine_2014



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