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Ophthalmology Xagena

Tocilizumab seems to be a promising therapy in severe and refractory non-infectious uveitis


A study has assessed the safety and efficacy of Tocilizumab ( Actemra; RoActemra ) in patients with severe and refractory non-infectious uveitis.

Eight consecutive unselected patients with severe and refractory non-infectious uveitis [ Birdshot chorioretinopathy ( n=1 ), Behçet's disease ( n=1 ) and idiopathic bilateral panuveitis ( n=6 ) ] treated with Tocilizumab ( 8mg/kg every 4 weeks intravenously ) were included.

The primary outcome was the response to treatment, defined by decrease of inflammatory ocular signs.

Four ( 50% ) patients were of female gender and the median ( IQR ) age was 41 years. The median number of previous immunosupressants was of 5.5.
Seven patients had been previously treated with anti-TNF-alpha [ Infliximab ( n=5 ) and Adalimumab ( n=2 ) ].
The immunosupressive drugs used in association with Tocilizumab were Azathioprine ( n=2 ), Mycophenolate mofetil ( n=2 ) and Methotrexate ( n=2 ).

After a median follow-up of 8 months, 6/8 ( 75% ) improved under Tocilizumab and 2 ( 25% ) were non-responders. The visual acuity improved in five patients.

The median dose of Prednisolone decreased from 16mg/day to 10 mg/day, at baseline and at the end of follow-up, respectively.

Tolerance of Tocilizumab was satisfactory and side effects included bronchitis ( n=1 ) and grade 1 leukopenia ( n=1 ) and thrombocytopenia ( n=1 ).

In conclusion, Tocilizumab seems to be a safe and promising therapy in severe and refractory non-infectious uveitis. ( Xagena )

Papo M et al, Clin Exp Rheumatol 2014;32 Suppl 84(4):75-79

XagenaMedicine_2014



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